Swansea manager Brendan Rodgers must decide whether to bring winger Scott Sinclair back into his starting line-up for the visit of the champions.
Sinclair, who has three goals to his name this season, was relegated to the bench for the goalless draw at Liverpool due to a tight hamstring, with Wayne Routledge impressing in his place.
Left-back Neil Taylor is fit after suffering an ankle knock at Anfield but the game comes too soon for centre-half Steven Caulker, who is still recovering from the knee injury he suffered at Arsenal in September.
Kemy Agustien is again in contention after returning from a hamstring problem, while fellow midfielder Stephen Dobbie is hoping for a place on the bench after overcoming an ankle injury.
Ashley Young will return from a toe injury when United visit Swansea for the first time since 1982.
Young has not featured since the derby mauling by Manchester City last month but has been training for a week and is expected to start.
Tom Cleverley (ankle) and Michael Owen (thigh) have both been ruled out until Christmas, Danny Welbeck has not recovered from the muscle strain he suffered on international duty, whilst Chris Smalling (foot) is unlikely to return until Tuesday's Champions League encounter with Benfica.
The match will be screened live on ESPN HD, with coverage underway from 4.30pm.
Swansea (from): Vorm, Williams, Taylor, Britton, Orlandi, Graham, Sinclair, Dyer, Dobbie, Routledge, Monk, Lita, Moore, Bessone, Rangel, Allen, Tremmel, Agustien, Gower, Richards, Moras.
United (from): De Gea, Lindegaard, Rafael, Fabio, Jones, Ferdinand, Vidic, Evans, Evra, Nani, Valencia, Gibson, Anderson, Carrick, Fletcher, Park, Giggs, Young, Rooney, Hernandez, Berbatov.