Andy Gray and Danny Drinkwater will both miss out through suspension.
Striker Gray and midfielder Drinkwater, on loan from Manchester United, have both reached five bookings for the season and will sit out respective one-game bans.
But Danny Haynes, Reuben Noble-Lazarus, Bobby Hassell and Goran Lovre could all return to the squad.
Haynes has been sidelined since early September with a hamstring injury and fellow striker Noble-Lazarus has been restricted to only two appearances, in August, this season due to an ankle problem.
Defender Hassell has recovered from a groin strain while midfielder Lovre is edging closer to his first appearance this season following a long-term knee injury.
Winger Jim O'Brien will also return to contention after missing the defeat at Brighton last time out due to suspension.
Doncaster look set to hand a debut to Carl Ikeme against the Tykes.
The Wolves keeper joined Rovers on a two-month loan last week and will be thrown into the starting line-up at Oakwell ahead of Neil Sullivan.
Midfielder Brian Stock should be ok for action despite not training due to a groin problem, though Chris Brown is struggling to make it after he withdrew from a behind-closed-doors game in midweek with a troublesome knee injury.
Martin Woods (groin) John Oster (neck) head the lengthy list of long-term injuries and boss Dean Saunders has bemoaned the injury plight at the club.
"I have never known as many injuries. The treatment room is full. The number of players with long-term injuries - I have never seen anything like it," he said.