Yeovil's goalkeeping coach Gareth Stewart will make his first Football League appearance in over three years against their local rivals.
The Glovers have been without a recognised stopper since Marek Stech returned to West Ham after his loan spell at Huish Park.
Stewart, 31, featured against Hereford in the FA Cup first round and kept a clean sheet in their 3-0 victory.
Manager Terry Skiverton is hopeful of landing a new keeper on loan but will not hesitate to play Stewart while he continues his search.
"Gareth came in and did very well at the weekend, and what we don't want to do is rush into anything," Skiverton told the Western Morning News.
Alan O'Brien (hamstring) is still out as is fellow midfielder Gavin Williams (knee) but loanee Conor Clifford will return to the fray after the midfielder returned from international duty with the Republic of Ireland Under-21s.
Jake Taylor will return to Exeter's squad for their derby clash in Somerset but manager Paul Tisdale has concerns over two of his players.
Striker Taylor, on loan from Reading, missed the FA Cup tie with Walsall as he was with the Wales Under-21 squad.
Fellow loanee Matt Oakley missed that contest with a thigh injury, while the same ailment restricted goalkeeper Artur Krysiak to the substitutes' bench.
Both will undergo late fitness tests to determine whether or not they will be involved with Lenny Pidgeley ready to carry on should Krysiak miss out.
Long-term injury absentees Richard Duffy (ankle), John O'Flynn (knee) and Liam Sercombe (broken metatarsal) were all involved in the FA Cup tie with the Saddlers and could play a key part in the Grecians' forthcoming fixtures.