Wayne Rooney and Nemanja Vidic are set to return for Manchester United.
Rooney missed Tuesday night's draw with Benfica with a hip injury sustained last week at Swansea whilst Vidic was ruled out through suspension.
However, both are included in a squad missing Anderson (knee), Michael Owen (thigh) and Tom Cleverley (ankle) as the Red Devils look to close the gap on leaders Manchester City to two points.
Gabriel Obertan will return to the Newcastle squad after missing the last two games with a toe infection.
Danny Guthrie should also make the game despite missing training this week because of a hip injury but Cheik Tiote (knee) and Leon Best (groin) remain doubts, while Sylvain Marveaux is expected to be sidelined for up to four months after undergoing groin surgery.
Man Utd (from): De Gea, Lindegaard, Rafael, Smalling, Fabio, Jones, Ferdinand, Vidic, Evans, Evra, Nani, Valencia, Gibson, Carrick, Fletcher, Park, Giggs, Young, Rooney, Hernandez, Berbatov.
Newcastle (from): Krul, Elliot, Simpson, R Taylor, Santon, Ferguson, Coloccini, S Taylor, Perch, Cabaye, Gutierrez, Gosling, Guthrie, Obertan, Ben Arfa, Abeid, Vuckic, Smith, Ba, Shola Ameobi, Lovenkrands, Sammy Ameobi.