Manager Derek McInnes is likely to stick with the same City side which returned victorious from Millwall when they face table-topping Saints.
The Robins have won three of McInnes' five games in charge so far, and the Scot does not have any pressing injury or suspensions concerns that would require him to change his starting XI.
Striker Jon Stead remains on the treatment table, however, and is a week away from a return to full training.
Defenders Louis Carey and Jamie McAllister both came through the club's reserve-team clash with Cheltenham in midweek after injuries, and are starting to push for a return to the first team. But it is unlikely either will feature for City against the high-flying Saints.
Fringe players Ryan Taylor (broken metatarsal) and Nicky Hunt (knee) remain sidelined.
But Dan Harding should return to the Southampton squad for the trip.
The full-back missed last weekend's 3-0 win over his former club Brighton after suffering a knee injury in training, but he is expected to be available.
Defenders Radhi Jaidi and Dan Seaborne and striker David Connolly are the only definite injury absentees.
Jaidi is still out following a recent knee operation and Seaborne is recovering from the head injuries he sustained in an assault in September.
Connolly will miss out again with a groin problem so Lee Barnard, who made his second substitute appearance of the season against Brighton after recovering from a long-term ankle injury, will be in the squad again.