Club captain John Eustace is set to return to Watford's starting XI, with Jonathan Hogg serving a one-match suspension.
Hogg has filled the midfield holding role in impressive fashion during Eustace's absence with a back injury, even restricting the fit-again skipper to a place on the bench for last weekend's 2-0 victory over Portsmouth.
But the former Aston Villa man picked up his fifth booking of the season in the triumph at Vicarage Road and must now serve an automatic ban.
Defender Lloyd Doyley will again be assessed prior to the encounter to determine whether he is ready to make his return from a thigh injury.
Centre-back Martin Taylor (dislocated collarbone) and midfielder Stephen McGinn (knee) remain long-term absentees.
Second-choice goalkeeper Rene Gilmartin completed a loan move to Yeovil on Thursday and will therefore not be on the bench, with manager Sean Dyche to decide whether Academy stopper Jack Bonham will provide back-up to number one Scott Loach in the matchday 16.
Habib Beye, Marc-Antoine Fortune and Herold Goulon, however, are ready to make their Doncaster debuts as boss Dean Saunders deals with a raft of injury problems.
Full-back Beye, 34, joined on loan from Aston Villa earlier this week, with 30-year-old West Brom attacker Fortune and 23-year-old Blackburn midfielder Goulon and also arriving at the Keepmoat Stadium on a temporary basis ahead of Thursday's emergency loan deadline.
Pascal Chimbonda is facing up to four weeks on the sidelines with a hip flexor problem, while James Coppinger, Billy Sharp, George Friend, Richard Naylor and Shelton Martis all picked up injuries in last weekend's 2-0 loss to Yorkshire rivals Barnsley.
Martis suffered is set for a month out with a groin injury and Coppinger, Friend (both foot), Sharp (groin) and Naylor (broken finger) are all major doubts.
Adam Lockwood was sent off at Oakwell at begins a three-match ban.
Rovers head into the match at the foot of the Championship, six points shy of safety.