Keith Andrews is set to return for Ipswich - but the encounter is likely to come too soon for Ibrahima Sonko.
On-loan midfielder Andrews, Town's second leading scorer this season with five goals, missed last weekend's late 3-2 loss at Nottingham Forest with a broken nose.
Centre-back Sonko, meanwhile, has not starred since the club's convincing defeat at Millwall at the end of October due to a persistent hamstring complaint.
Manager Paul Jewell told the club's official website: "Keith is okay and he trained with us on Wednesday. Obviously he had a bang on his nose but he's had the operation and he feels fine now, which is good.
"Sonko has trained with us for the first time since he got injured against Millwall but we will have to be careful with him. We will see how he is but Saturday may come too early for him as he hasn't trained too much since the injury."
It has been a busy couple of days at Portman Road and goalkeeper Richard Wright comes into contention for the clash having has re-signed until the end of the season. However, Tamas Priskin, Ronan Murray and Shane O'Connor have departed on loan while Colin Healy's contract has been ended by mutual consent.
Reading, meanwhile, are sweating over the fitness of Joseph Mills.
Full-back Mills has picked up an ankle injury which will be assessed prior to the match at Portman Road.
Should the young defender not be fit enough to feature in the clash, Ian Harte is likely to deputise.
Meanwhile, Brynjar Gunnarsson remains sidelined with the calf strain he picked up in a reserve-team fixture a fortnight ago, but centre-back Bongani
Khumalo has returned to training following the ankle problem which prevented him playing for South Africa recently.
Young striker Nicholas Bignall is also out of contention as he recovers from the knee surgery which cut short his loan spell at Wycombe.