Saints manager Steve Lomas has doubts over Cillian Sheridan and Jody Morris for his first home match in charge.
Sheridan missed last week's draw at Ibrox with a tight hamstring and Lomas will assess the striker in training.
Morris went off with a hamstring problem and Saints will give their captain until the last minute.
New manager Pat Fenlon will watch on from the stands as Billy Brown takes charge of Hibs for the final time.
Brown, who as caretaker boss saw Hibs draw 1-1 with Kilmarnock last weekend, has a full squad to choose from.
Striker Garry O'Connor was ill during the week but is expected to be fit for contention.
Saints (from): Enckelman, C Davidson, Maybury, Mackay, Anderson, Morris, Gibson, Craig, Moon, Millar, Sheridan, Sandaza, Haber, Caddis, May, Mannus, M Davidson, Wright.
Hibs (from): Stack, Murray, O'Hanlon, Hanlon, Sproule, Wotherspoon, Palsson, Osbourne, Scott, O'Connor, Sodje, Galbraith, Griffiths, Agogo, Brown, Stevenson, Stephens, Towell, Booth, Thornhill, Hart, Welsh.