Middlesbrough will make a late decision on Barry Robson.
The midfielder played the full 90 minutes in the 1-1 draw at Peterborough but has since experienced tightness in his thigh.
Marvin Emnes was substituted at London Road with the striker complaining of a calf injury and he too will be assessed before boss Tony Mowbray names his starting XI.
Scott McDonald is hoping to recover from illness to resume his place up front but midfielder Kevin Thomson is unlikely to return from the hamstring injury which has sidelined him for the last six matches.
Full-back Justin Hoyte (hamstring) was fit enough for a place on the bench on Saturday and looks set to be named among the substitutes again for the visit of the Hammers.
Mowbray's men are five points behind the east London outfit following a four-match unbeaten run.
West Ham are looking to secure their fourth win in a row but boss Sam Allardyce has some injury problems to deal with.
Midfielder Matt Taylor returned from a calf injury to play the last eight minutes of the 3-1 win over Derby at the weekend but he is likely to have to settle for a place on the bench again.
Carlton Cole was handed a start in attack against the Rams and responded by scoring the equaliser on the stroke of half-time, ensuring he will be at the forefront of the manager's mind for the trip to the Riverside.
The Hammers were boosted by the return of right-back Joey O'Brien on Saturday and he completed 90 minutes for the first time since recovering from a hamstring injury.
Winston Reid (shoulder), Gary O'Neil (ankle), Henri Lansbury and David Bentley (both knee) are still out.
Following Southampton's loss against Bristol City, Allardyce's side are just two points off the Championship summit.