Striker Danny Graham is a major doubt for the Swans.
The former Watford striker is struggling with the Achilles injury he suffered in last weekend's goalless draw with Aston Villa, with Leroy Lita likely to lead the line in his absence.
Right-back Angel Rangel is facing a month out after picking up an ankle problem in the same game so Wales Under-21 captain Jazz Richards is set for a first Premier League start.
Blackburn boss Steve Kean hopes to have a trio of defenders available again.
Christopher Samba, Martin Olsson and Michel Salgado could all return to the Rovers backline after being sidelined by hamstring problems.
Forward Junior Hoilett is doubtful due to the virus which ruled him out of Tuesday's Carling Cup defeat at Cardiff, while Steven Nzonzi serves the second game of his three-match suspension.
Rovers (from): Robinson, Bunn, Olsson, Samba, Lowe, Dann, Salgado, Givet, Hanley, Rochina, Pedersen, Petrovic, Dunn, Hoilett, Yakubu, Goodwillie, Formica, Roberts, Vukcevic, Slew, Blackman, Henley.
Swansea (from): Vorm, Williams, Taylor, Britton, Orlandi, Graham, Sinclair, Dyer, Dobbie, Routledge, Monk, Lita, Moore, Bessone, Allen, Tremmel, Agustien, Gower, Richards, Moras.