Callum McManaman and Kevin Phillips are vying for a place in the Blackpool attack.
The Seasiders' preparations for the Championship clash were dealt a blow when Liverpool recalled Jonjo Shelvey from his loan spell on Wednesday.
The 19-year-old playmaker hit six goals in nine appearances for the Seasiders, revelling in the freedom afforded to him in a three-man forward line.
On-loan Wigan youngster McManaman starred alongside Shelvey and Lomana LuaLua when Ian Holloway's men romped to a 5-0 win at Elland Road last month, while veteran striker Phillips remains Blackpool's joint top scorer - alongside Shelvey - despite being restricted to bench duty in recent weeks.
Chris Basham could come into the Tangerines' defence after replacing Alex Baptiste (hamstring) in the first half of Tuesday night's defeat at Leicester.
Craig Cathcart (thigh) is back to full fitness and could also step in if the game comes too soon for Baptiste, while midfielder Keith Southern is available following illness.
Reading will be without captain Jobi McAnuff.
Winger McAnuff picked up his fifth booking of the season in the 3-2 victory over Peterborough in the Championship on Tuesday and serves a one-match ban so Kaspars Gorkss will skipper the team in his absence.
Hal Robson-Kanu, who scored a sublime goal after coming on as a second-half substitute in the defeat of Posh, is likely to deputise for McAnuff wide on the left.
Full-back Joseph Mills remains a doubt for Royals manager Brian McDermott with an ankle knock which has kept him out of Reading's last two matches. Veteran defender Ian Harte will continue to deputise for Mills should he fail to recover in time for the match at Bloomfield Road.
Midfielder Mikele Leigertwood was substituted with a minor injury problem on Tuesday but is unlikely to miss out for the Berkshire outfit, but young striker Nicholas Bignall remains sidelined following the knee surgery which prematurely ended his loan spell at Wycombe.