Sam Baldock is ruled out but John Carew could return when the Hammers host Eddie Howe's Clarets.
Baldock faces three weeks on the sidelines with a hamstring problem but fellow striker Carew should be available after resting a knee injury at Middlesbrough in midweek.
Carew will probably be on the bench with one or both of Frederic Piquionne and Carlton Cole, the goalscorers in the 2-0 win on Tuesday night, starting up front.
Guy Demel could keep his place at right-back after an encouraging debut at the Riverside and midfielder Jack Collison is pushing for a return to the starting line-up.
Defender Winston Reid (shoulder), winger Gary O'Neil (ankle) and on-loan midfielder Henri Lansbury (knee) are still out.
Marvin Bartley faces a late fitness test for Burnley.
The midfielder hobbled off shortly after half-time in the Clarets' emphatic 4-0 win over Ipswich on Tuesday night, suffering from a tight calf.
Ross Wallace is available once more having served a one-match suspension for that game, but superb wing displays from Junior Stanislas and Keith Treacy mean the Scotland international might have to be content with a place on the bench.
Charlie Austin (dislocated shoulder) and Martin Paterson (thigh) are back in training, but next weekend's game with Portsmouth has been set as the realistic target for the forward duo.
And boss Eddie Howe appears more than happy to continue with current strike pairing Jay Rodriguez and Sam Vokes at Upton Park after both were on target against the Tractor Boys.
"Sam and J-Rod to have hit it off straight away, they've formed a good partnership," he said. "I thought Sam was excellent (against Ipswich) and I'm pleased he's got his first goal."