Kilmarnock will be without midfielders Danny Buijs and Liam Kelly.
Buijs has been ruled out for four to six weeks with a hamstring injury, while Kelly is struggling with with a virus.
However, defender Mohamadou Sissoko has recovered from a similar illness ahead of the visit of the Dons.
Aberdeen manager Craig Brown will make a late decision on a number of players.
Midfielder Kari Arnason (hamstring), striker Rory Fallon (groin) and full-back Ryan Jack (toe) have all been struggling with injury, while striker Scott Vernon and midfielder Fraser Fyvie are both nursing knocks.
Brown is hoping at least some of that group will be able to make the trip to Rugby Park.
Kilmarnock (from): Bell, McKeown, Hay, Fowler, Sissoko, Harkins, Shiels, Racchi, Silva, Pascali, Heffernan, Gros, Pursehouse, Dayton, Jaakkola, Kroca, Fisher, Kennedy.
Aberdeen (from): Gonzalez, Foster, Considine, Mawene, Osbourne, Clark, Milsom, Jack, Pawlett, Fyvie, Magennis, Fallon, Mackie, McArdle, Robertson, Grimmer, Brown, Megginson, Arnason, Vernon.