Jack Rodwell has been ruled out for Everton after aggravating a hamstring injury during the warm-up against Norwich at the weekend.
Young striker Conor McAleny (hamstring) is also unlikely to feature but midfielder Seamus Coleman is set for a return after a thigh injury.
Angel Rangel could replace Jazz Richards in Swansea's starting line-up after making a rapid recovery from the ankle injury he suffered in last month's goalless draw with Aston Villa.
Nathan Dyer is set to miss out with a foot problem, meaning Wayne Routledge and Scott Sinclair are likely to retain the wing slots.
Everton (from): Howard, Hibbert, Heitinga, Jagielka, Baines, Bilyaletdinov, Neville, Cahill, Fellaini, Coleman, Saha, Distin, Drenthe, Osman, Barkley, Osman, Gueye, Mucha, Stracqualursi, Vellios.
Swansea (from): Vorm, Williams, Taylor, Rangel, Caulker, Britton, Orlandi, Graham, Sinclair, Dobbie, Routledge, Monk, Lita, Moore, Bessone, Allen, Tremmel, Agustien, Gower, Richards, Moras.