Leeds defender Tom Lees is expected to return to the side.
Lees missed Saturday's 4-1 defeat at Barnsley due to concussion sustained at Derby on Boxing Day, but is likely to return to help shore up Leeds' leaky defence.
Manager Simon Grayson said he was "embarrassed" by his players' performance at Oakwell and can be expected to make several other changes as Leeds look to halt a run of three straight defeats.
Winger Robert Snodgrass remains sidelined following his appendix operation on Thursday, as does skipper Jonny Howson, who has missed the last four games due to a knee injury.
Midfielder Adam Clayton and striker Luciano Becchio could return to the starting line-up and Grayson may include Alex Bruce in his back four following his early recall from his loan spell at Huddersfield.
New loan signing Andros Townsend goes straight into the squad.
Leeds have slipped to 10th place in the table, four points adrift of the play-offs, after taking only one point from their last four matches.
Defender Michael Duff remains Burnley's only injury concern.
A hamstring problem ruled Duff out of the Claret's 1-0 triumph over Hull on New Year's Eve - a victory that stretched their current purple patch to six wins in seven matches - and he will be assessed before the Elland Road clash.
Elsewhere competition for places in Eddie Howe's matchday squad is rife, with winger Junior Stanislas targeting a return to the 16 after Keith Treacy took his starting berth against Hull.
Howe is relishing a Roses battle that is sure to be played out before a fervent crowd.
"The game against Leeds last was the first time that I've sampled that atmosphere at Elland Road and I thought it was a great game and a great atmosphere," he said.
"We'll be very keen to go there and try and get a positive result. It would mean everything to us and our supporters so hopefully we can do that."