Chris Hackett faces a race against time to be fit for Exeter's West Country derby.
The on-loan Millwall winger was passed fit to face Colchester on Saturday despite struggling with a knee injury, but was replaced by Daniel Nardiello after just 19 minutes at the Weston Homes Community Stadium.
If Hackett is ruled out, Nardiello could start, although the striker was replaced by John O'Flynn 57 minutes after entering proceedings.
Manager Paul Tisdale will be without the suspended defender Danny Coles, who was dismissed during the 2-0 defeat at Colchester for a professional foul on Karl Duguid and serves a one-match suspension.
Steve Tully may earn a promotion from the substitutes' bench to take Coles' place in City's defence.
Meanwhile, Yeovil manager Terry Skiverton is still without a trio of players.
Defender Kerrea Gilbert and midfielders Paul Wotton and Ed Upson are all on the sidelines through suspension.
Gilbert serves the final game of a three-match ban after his sending off against Rochdale on December 17, while Wotton and Upson complete their respected two-match punishments following their accumulation of 10 yellow cards.
Midfielder Conor Clifford was replaced after just 40 minutes against Bournemouth on Saturday and may drop to the bench, with his replacement Steven MacLean possibly earning a promotion to the starting line-up.
Striker Gavin Massey was a second-half substitute against the Cherries and may be given the nod to face Paul Tisdale's side.