Sheffield Wednesday goalkeeper Stephen Bywater will return to contention after joining the club on a free transfer.
Bywater recently completed a three-month loan deal from Derby and missed Saturday's win at Preston, but is expected to return to the starting line-up against Tranmere in place of Nicky Weaver.
Manager Gary Megson is hoping skipper Rob Jones can prove his fitness after missing out on New Year's Eve due to a back problem.
Llera, on loan from Blackpool, will continue at the heart of defence if Jones fails to make it.
Jon Otsemobor made his first league start of the season at Preston and is hoping to retain his place at full-back.
Megson has no new injury or suspension problems as his side look to keep pace with city rivals Sheffield United in the race for automatic promotion.
Meanwhile, Tranmere boss Les Parry does not expect any of his injury absentees to return for the match.
Midfielder John Welsh will miss out with a knee problem, while striker Enoch Showunmi (leg), defender Ian Goodison (hamstring) and goalkeeper Owain Fon Williams (hand) remain sidelined.
Showunmi received a boost this week when x-rays revealed he had not suffered a broken leg as was first feared, but Parry confirmed he still has work to do to return to fitness.
"There's no break with Enoch, but he's still got a lot of swelling there," the Rovers manager told Tranmere player. "He was trying to kick a ball on Friday and every time he did was hobbling."
Defenders Zoumana Bakayogo and David Raven returned from lay-offs to take places on the bench for the 2-0 win over Bury, but Parry admitted the pair are a way off match fitness.
He added: "We put Raven on the bench because he was the fittest of our defenders, though he wasn't fit and we were praying that we didn't have to use him, and exactly the same with Zoom."