Midfielder Liam Sercombe is a doubt for Exeter. Sercombe was withdrawn after 16 minutes of the Grecians' goalless draw against Hartlepool on January 14 with a hamstring injury and the midfielder is touch-and-go to make the clash with the Addicks.
Otherwise, manager Paul Tisdale has a fully-fit and suspension-free squad at his disposal and is spoilt for choice in the striking department.
Daniel Nardiello, John O'Flynn and Richard Logan are all vying for starting berths up top, as the Grecians go into the match hoping to extend their unbeaten streak to five matches.
Goalkeeper Artur Krysiak is also looking to preserve an impressive run of three consecutive clean sheets for the hosts.
Meanwhile, leaders Charlton will be without Darel Russell.
The on-loan Preston midfielder came on as a late substitute during last weekend's 1-0 win over Sheffield United and promptly got himself sent off to earn a three-match ban.
Russell's absence could see a return to the squad for Dale Stephens, who has recently recovered from an ankle injury but was not risked on Saturday.
Boss Chris Powell has no new injury worries and may stick with the same starting XI which sent them seven points clear at the top of League One.
Striker Danny Haynes, the recent signing from Barnsley, made his debut from the bench against the Blades and is set to be among the substitutes again.