Wednesday manager Gary Megson has hinted at several changes for the home clash.
Megson's side, who lost ground in the automatic promotion race after a 2-1 defeat at Exeter at the weekend, could be without defender Miguel Llera.
The centre-half was forced off at Exeter due to concussion and is rated 50/50. Skipper Rob Jones stepped off the bench and will continue alongside Danny Batth if the Spaniard fails to make it.
Megson has no other new injury or suspension worries, but defender Reda Johnson will sit out the second game of a two-match ban.
Jon Otsemobor is pushing for a recall at right-back after missing out altogether at the weekend and both midfielder Chris Lines and striker Ryan Lowe are pushing for returns to the starting line-up.
The Owls are in second place, a point above Sheffield United, but have played two games more than their rivals.
Gary Smith will finally take charge of his first league game as Stevenage manager.
Smith, who replaced Graham Westley towards the end of last month, began his Boro reign against Notts County in the FA Cup on January 28 and that remains the only game during his short time at the helm.
The former Colorado Rapids boss named an unchanged line-up against the Magpies having watched from the stands as Stevenage came from behind to beat MK Dons in captain Mark Roberts' final game as caretaker player-manager.
Smith is again expected to keep any changes to a minimum and could even name the same team again.
However, defender Phil Edwards, midfielders Stacy Long, Robin Shroot and Chuks Aneke as well as strikers Ben May, Don Cowan and Robert Sinclair are options for Smith should he wish to make any changes.