Chesterfield will check on the fitness of James Hurst ahead of the match.
Hurst missed the 1-1 draw at Bury in midweek with an ankle knock and the on-loan West Brom defender will continue to be monitored ahead of the Saturday lunchtime kick-off.
Mark Allott had not sufficiently recovered from a thigh problem to be considered on Tuesday night but the experienced midfielder is expected to be available against the Owls.
French midfielder Jimmy Juan is progressing well as he bids to overcome a calf injury but this game is likely to come too soon for him.
The match is at the B2net Stadium and chief executive Chris Turner said: "We can expect a cracking atmosphere for the first visit by the Owls to our new stadium.
"We hope that everyone has an enjoyable afternoon for what will be our biggest crowd of the season."
Meanwhile, Sheffield Wednesday defender Reda Johnson is expected to return to the starting line-up at Chesterfield.
Johnson missed the Owls' back-to-back defeats last week due to a two-game ban, but is likely to slot in at left-back with Lewis Buxton switching to the right and Jon Otsemobor possibly dropping to the bench.
Midfielder John Bostock, on loan from Tottenham, missed the midweek home defeat to Stevenage through illness and remains doubtful, as does striker Ryan Lowe, who is struggling to shake off a bruised calf.
Central defender Miguel Llera, on loan from Blackpool, missed out on Tuesday night due to a nasty cut above his eye that required stitches and he too is 50/50.
Manager Gary Megson has no other new injury or suspension problems as Wednesday, two points behind second-placed Sheffield United having played two games more, look to get their promotion challenge back on track.