Fulham midfielder Steve Sidwell has suffered an injury setback that looks likely to rule him out for a further four weeks.
The 29-year-old was closing in on a return but has had to have another operation on a hernia injury, putting his rehabilitation back.
Aaron Hughes returns to the squad after missing last weekend's defeat to Aston Villa with a calf complaint, while Zdenek Grygera is out for the rest of the season with a knee injury. Orlando Sa is out for at least three or four weeks with a hamstring injury.
Swansea have no fresh concerns heading into the clash.
The Welsh outfit came out of last weekend's 1-0 win over Manchester City unscathed, but will again be without winger Nathan Dyer through suspension.
Andrea Orlandi is back in training after a hamstring tear, while Kemy Agustien is likely to miss the rest of the season after ankle surgery.
Fulham (from): Schwarzer, Stockdale, Kelly, Riise, Hangeland, Senderos, Hughes, Baird, Murphy, Etuhu, Diarra, Gecov, Kasami, Frei, Dempsey, Ruiz, Davies, Duff, Dembele, Johnson, Pogrebnyak.
Swansea (from): Vorm, Williams, Taylor, Caulker, Tate, Britton, Graham, Sinclair, Routledge, Monk, McEachran, Lita, Moore, Bessone, Rangel, Situ, Allen, Tremmel, Gower, Richards, Sigurdsson, Obeng.