Carlisle could be boosted by the return to contention of skipper Paul Thirlwell and Matty Robson.
Midfielder Thirlwell has missed the last seven matches due to a calf injury, while left-back Robson has been sidelined since early January with back trouble.
Manager Greg Abbott, who has no new injury or suspension problems, could be tempted to hand on-loan Sunderland striker Jordan Cook his third start for the club after he stepped off the substitutes' bench to fire two late goals in the midweek win at play-off rivals MK Dons.
Danny Livesey is expected to retain his place in central defence alongside Peter Murphy, meaning a place on the bench again for Slovakia international Lubo Michalik.
The Cumbrians' midweek win lifted them three points clear of seventh-placed Stevenage in the race for a top-six finish.
Huddersfield manager Simon Grayson will select his starting XI from an unchanged squad.
Midfielder Tommy Miller is closing in on a return to first-team action for the first time since early February following a double hernia operation but will require at least one reserve-team run out before being considered for the matchday squad.
Oscar Gobern is still sidelined with hamstring and back trouble that has kept him out of the last five matches and fellow midfielder Damien Johnson is out for the rest of the season with a torn hamstring.
Defender Gary Naysmith is also sidelined after recently sustaining a knee injury.
Recent loan signing Diego Arismendi looks set to continue in central midfield alongside Antony Kay after making his first start in last week's win over Charlton.
The Terriers are in fourth place, three points behind second-placed Sheffield United with a game in hand.