Carlisle will be without leading goalscorer Lee Miller.
Miller, who has scored 15 goals this season, sustained a groin injury in Monday's goalless draw with Scunthorpe and has been ruled out for the rest of the season.
Paddy Madden replaced Miller on Monday but manager Greg Abbott could be tempted to start with Jordan Cook, on loan from Sunderland, up front alongside Francois Zoko.
The Cumbrians will also be without left-back Chris Chantler, who will miss the final four games of the campaign with a hamstring problem.
Another left-back, Matty Robson, has been sidelined all year with back trouble, so manager Abbott will continue with centre-half Danny Livesey in that role, with Lubo Michalik resuming his partnership with Peter Murphy in central defence.
Midfielder Paul Thirlwell, who has missed the last 10 games, is still out with a long-term calf injury.
The Cumbrians are level on points with sixth-placed Notts County but have a game in hand.
Charlton will welcome back winger Scott Wagstaff from suspension as they attempt to seal promotion.
Wagstaff missed the Easter Monday win over Walsall after he was sent off for two bookable offences against Oldham 48 hours earlier.
But the Addicks are still without Danny Hollands, who copped a three-match ban for his straight red card in the same game, and fellow midfielder Darel Russell, who is still serving a four-match suspension.
Winger Danny Green could return to the squad after he was unwell over the Easter weekend.
The Addicks, currently six points clear at the top, will be assured of promotion back to the Championship if they win and third-placed Sheffield Wednesday fail to beat Colchester.