Defender Ryan Cresswell will return to the Rotherham side as they bid farewell to Don Valley.
The centre-back missed last weekend's 2-2 draw with Aldershot as he was serving a one-match suspension but he is now ready to return to the back-four as the Millers play their last game in Sheffield.
Left-back Tom Newey begins a one-match ban following his red card against the Shots, so Scott Griffiths, Sam Wood or Dale Tonge will deputise.
Michael Raynes has recovered from a hamstring injury, but boss Steve Evans is not likely to start with the defender, while striker Lewis Grabban (virus) faces a late assessment.
Don Valley has been the Millers' home for four years following their decision to leave Millmoor in 2008, but they will return home next season as they move to the brand new 12,000-seater New York Stadium in the heart of the town.
Meanwhile, Michael Jacobs is in line to make his 100th appearance for Northampton.
Town fans will be hoping it is not the last they see of the 20-year-old midfielder, who will be out of contract in the summer and has attracted the interest of several Championship clubs this season.
Teenage forward Lewis Wilson will be hoping to keep his place in the starting line-up after scoring on his full debut in last weekend's 1-1 draw with Gillingham.
Wilson should be fit despite going off with an eye injury to be replaced by fellow striker Brett Williams, who had a loan spell at Rotherham earlier this term.
Boss Aidy Boothroyd could make changes with the likes of Byron Webster, Ben Harding and Jake Robinson pushing for recalls.