Paul Jewell will be without four players but plans to use the tie as a chance for fringe players and youth to impress.
Goalkeeper David Stockdale, who would not have been eligible to play in any case under the terms of his loan from Fulham, has been named in Fabio Capello's England squad for their friendly against Holland on Wednesday.
Centre-back Damien Delaney, who also would have been away with the Republic of Ireland but has been forced to withdraw, misses out due to an ankle injury sustained in Saturday's 3-0 win at Bristol City. It is hoped he will be fit to face Hull this weekend.
Forward Tamas Priskin and the versatile Josh Carson are also away on international duty with Hungary and Northern Ireland's Under-21 squad respectively.
Jewell has admitted he will make changes against the Cobblers, meaning Arran Lee-Barrett will start in goal and the likes of Tommy Smith, Colin Healy and Nathan Ellington, among others, are set to come in.
Northampton captain John Johnson is a major doubt.
The defender is nursing a dead leg following the goalless home draw against Accrington on the opening day of the season.
"Jonno has got a hematoma of the thigh which might stay around for a few days yet," said Cobblers boss Gary Johnson. "We will keep an eye on it but we have got two or three options.
"I don't want to change the team around too much but it might be a chance for Ashley Westwood or Nick McKoy to come in, or Ben Tozer could also move back there.
"We are a little bit thin on the ground in terms of numbers but generally I don't tend to rest players for the sake of it. I like to try and keep that continuity and I only tend to leave players out if they have picked up a knock and can't play because of injury.
"We can't make wholesale changes anyway but even if we could I probably wouldn't in this instance."