Midfielder Robbie Williams is a doubt for Plymouth after aggravating a heel injury in their season-opener at Shrewsbury.
Williams, who was making his debut for the south-coast side, had been struggling from a bruised heel in the build up to the game and was replaced at half-time by Simon Walton.
Walton is favourite to claim a place in the starting line-up should Williams fail to prove his fitness.
The 23-year-old could be the only change from his side's 1-1 draw, where Plymouth avoided an opening-day defeat for the ninth consecutive season.
The Pilgrims are hoping to upset Championship outfit Millwall and progress to the second round of the cup for the first time since 2007.
Millwall will be without goalkeeper David Forde for the trip.
Forde is on international duty with the Republic of Ireland squad to face Croatia so Steve Mildenhall is in line to make his first appearance since joining the Lions more than a year ago.
Striker Josh McQuoid was called up to the Northern Ireland squad but has since pulled out with a hamstring problem.
Boss Kenny Jackett will consider making changes so defender Jordan Stewart and midfielder Therry Racon, who both sat out the 2-2 draw at Reading on Saturday, could make their debuts.
Forward Shaun Batt is the only long-term absentee and he is back in training after a cruciate injury ruled him out for all of last season.