Doncaster could hand debuts to Chris Kirkland, Herita Ilunga and Pascal Chimbonda when they host Leeds on Friday night.
Former England goalkeeper Kirkland has joined Rovers on loan until January from Wigan, while left-back Ilunga arrived from West Ham on a similar deal before the international break.
Chimbonda signed a short-term deal at the Keepmoat at the end of September, but and was not picked for Rovers' 2-1 win at Peterborough in their last outing due to a lack of fitness.
Kirkland's arrival gives manager Dean Saunders a selection headache after veteran Neil Sullivan put in a stellar performance at London Road, while James Chambers and George Friend could be the ones to make way for Ilunga and Chimbonda.
Chris Brown, James Chambers, Martin Woods and Adam Lockwood are long-term absentees and will be unavailable for Saunders once more.
Leeds winger Robert Snodgrass is hoping to shake off an ankle injury in time for the game.
Snodgrass was forced to withdraw from the Scotland squad last week due to a problem aggravated in Leeds' 1-0 win over Portsmouth in their last match, but the Scot could still play a part in the Yorkshire derby.
Manager Simon Grayson has no other new injury or suspension concerns and expects all his international players to be in contention.
Central defender Darren O'Dea and striker Andy Keogh have reported back fit from Republic of Ireland duty while forward Mikael Forssell and midfielder Mika Vayrynen were scheduled to return to training on Thursday having featured for Finland in their Euro 2012 qualifiers against Hungary and Sweden.
Left-back Aidy White has been away with the Republic of Ireland Under-21s and fellow defender Charlie Taylor is hoping to be in the squad having been included in Noel Blake's England Under-19s squad for a tournament in France.