Luka Modric looks set to make his first Tottenham appearance of the season on Sunday after taking part in full training on Friday.
The wantaway Croatian has been carrying what has been officially diagnosed as a minor hamstring complaint but should be fit, along with Jermaine Jenas and Alan Hutton, who have recovered from recent Achilles and knee injuries respectively
William Gallas (calf), Steven Pienaar (groin), Ledley King, Wilson Palacios and Sandro (all knee) miss out while loan signing Emmanuel Adebayor is unavailable to play against his parent club.
New signing Samir Nasri could make his Manchester City debut.
Midfielder Nigel de Jong is out with a foot problem but manager Roberto Mancini has no other injury concerns.
Carlos Tevez could also feature but is again likely to be on the bench due to a lack of match sharpness.
Tottenham (from): Gomes, Friedel, Cudicini, Bale, Kaboul, Bassong, Dawson, Corluka, Walker, Hutton, Assou-Ekotto, Huddlestone, Lennon, Van der Vaart, Modric, Jenas, Kranjcar, Livermore, Townsend, Bentley, Pavlyuchenko, Crouch, Defoe, Dos Santos.
Man City (from): Hart, Richards, Zabaleta, Savic, Kompany, Lescott, Clichy, Kolarov, Boyata, Johnson, Barry, Milner, Silva, Y Toure, Wright-Phillips, Balotelli, Dzeko, Aguero, Tevez, Pantilimon, Taylor.