Darren Fletcher will return to Manchester United's squad for the game.
The Scotland skipper has struggled to shake off the effects of a virus he was struck down by in March but, after coming through his second 90-minute reserve-team outing on Thursday night against Swansea, has been drafted into manager Sir Alex Ferguson's plans.
Rio Ferdinand (hamstring) and Antonio Valencia (ankle) have been training, but Nemanja Vidic (calf) and Rafael (shoulder) are definitely out.
Alex Song, Gervinho and Emmanuel Frimpong are suspended for the Gunners.
Jack Wilshere saw a specialist on Friday but the club are still waiting for an update on his ankle injury which is expected to keep him out for three more weeks.
Nicklas Bendtner is sidelined with an ankle problem and Sebastien Squillaci is also out, along with Kieran Gibbs (hamstring) and Abou Diaby (ankle).
Defender Thomas Vermaelen will have a fitness test tomorrow but is expected to be fit and Laurent Koscielny came through a similar check on his back problem on Friday morning.
United (from): De Gea, Lindegaard, Smalling, Ferdinand, Jones, Evra, Evans, Fabio, Nani, Park, Cleverley, Anderson, Carrick, Fletcher, Giggs, Young, Rooney, Berbatov, Welbeck, Diouf, Owen, Macheda.
Gunners (from): Szczesny, Jenkinson, Djourou, Koscielny, Vermaelen, Sagna, Walcott, Arshavin, Rosicky, Ramsey, Traore, Van Persie, Lansbury, Fabianski, Oxlade-Chamberlain, Chamakh, Miquel, Miyaichi.