Sir Alex Ferguson has reported no fresh injury concerns ahead of United's showdown with Chelsea.
Nemanja Vidic (calf), Tom Cleverley (foot) and Rafael (shoulder) remain sidelined, whilst Danny Welbeck (hamstring) is not expected to be available until next week.
Changes are anticipated though, with Ferguson expected to recall many of the players who were left out of his starting line-up for the midweek Champions League draw with Benfica.
Chelsea will once again be without Didier Drogba for the game.
The striker will not be risked at Old Trafford three weeks after his sickening head injury, meaning manager Andre Villas-Boas must decide whether to start Fernando Torres or Nicolas Anelka.
Ramires returns after being suspended for Tuesday's Champions League win over Bayer Leverkusen, while goalkeeping understudies Hilario and Ross Turnbull are both carrying knocks, although one will be on the bench.
Man United (from): De Gea, Lindegaard; Evans, Evra, Fabio, Jones, Smalling, Ferdinand, Anderson, Carrick, Fletcher, Giggs, Nani, Park, Valencia, Young; Berbatov, Hernandez, Owen, Rooney.
Chelsea (from): Cech, Ivanovic, Bosingwa, Ferreira, Terry, Luiz, Alex, Cole, Mikel, Romeu, McEachran, Ramires, Lampard, Meireles, Mata, Malouda, Torres, Anelka, Sturridge, Kalou, Lukaku, Hilario, Turnbull.