St Johnstone will be without Frazer Wright.
The defender was forced out of the midweek Scottish Communities League Cup tie against St Mirren with a torn calf and faces between four and six weeks on the sidelines.
Jody Morris, Kevin Moon, Sam Parkin, Callum Davidson, Graham Gartland and Murray Davidson are all likely to remain on the sidelines this weekend.
Andy Webster and Andrew Driver have been passed fit for Hearts ahead of the trip to Perth.
Webster pulled out of last week's win over St Mirren after suffering pain in the warm-up but he is in full training and Driver came through Wednesday's Scottish Communities League Cup tie against Ayr with no reaction to a knee problem.
Marian Kello, Kevin Kyle, Gary Glen and Calum Elliot remain on the sidelines.
St Johnstone (from): Enckelman, Maybury, MacKay, Anderson, Adams, Craig, Millar, Haber, Sheridan, Higgins, Sandaza, Gibson, May, Mannus, McIntosh, Caddis, McCracken, Robertson.
Hearts (from): MacDonald, Hamill, Grainger, Zaliukas, Taouil, Skacel, Black, Obua, Jonsson, Stevenson, Mrowiec, Elliott, Templeton, Robinson, Smith, Webster, Novikovas, Balogh.