Charlton boss Chris Powell will make changes for the game.
Powell has named the same starting line-up for the Addicks' opening four League One fixtures, picking up three wins and a draw against Scunthorpe on Saturday.
Defender Andy Hughes, midfielder Bradley Pritchard, winger Danny Green and striker Jason Euell could all get their first starts of the season along with full-back Cedric Evina, who missed the beginning of the campaign with a slight knee injury.
Powell must decide whether to give Paul Benson a run-out after revealing the striker will be allowed to leave the club.
Powell confirmed there has been interest in the former Dagenham man but no firm bids have been received.
Reading manager Brian McDermott is without Andy Griffin.
The defender, who injured his hamstring against Portsmouth, missed the 2-1 home defeat to Barnsley at the weekend and is likely to be occupying the sidelines for at least another week.
Fellow defender Shaun Cummings is hoping to play some part at the Valley despite carrying a little niggle, while Marcus Williams misses out through injury.
The Royals welcomed Simon Church back into their squad against the Tykes following a thigh injury and, after the Wales international came off the bench, he is pushing for a start in attack.
Fellow frontman Mathieu Manset, who was also a second-half substitute against Keith Hill's side, may also be given a starting role against the Addicks.