Phil Parkinson will go into his first match in charge of Bradford with no fresh injury concerns.
The former Charlton boss took over from Peter Jackson, who resigned after the Bantams collected just one point from their opening four league games.
Bradford began life without Jackson on Saturday by claiming their first three-point haul of the campaign, beating Barnet 4-2.
Parkinson will be without defender Simon Ramsden (calf) along with midfield duo Martin Bullock (hip) and David Syers (knee), who are all long-term absentees.
Centre-back Steve Williams is still working his way back from a thigh injury and will probably miss out.
Goalkeeper, Oscar Jansson, on loan from Tottenham, made his debut in the win over the Bees and could retain his place between the posts.
Manager Gary Megson has no fresh injury concerns as Sheffield Wednesday bid to win their first game on the road this season.
Rob Jones returned from a broken nose to face his former club Scunthorpe and completed 90 minutes in the 3-2 win on Saturday.
His inclusion was the only change Megson made from the team which defeated Notts County 2-1.
But Megson has made multiple changes to his starting XI in cup competitions this season and several fringe players could be handed a start against the Bantams.
Jermaine Johnson could make his first appearance of the campaign after returning to full training.
The likes of Jon Otsemobor, Reda Johnson, James O'Connor and Giles Coke will be hoping to start.