Aaron Ramsey and Tomas Rosicky have both been ruled out for the Gunners.
Ramsey limped out of training on Monday with an ankle complaint and has not been included in the 18-man squad along with Rosicky, who is struggling with a knee injury.
Thomas Vermaelen and Jack Wilshere are other key players also missing, although new signings Mikel Arteta, Per Mertesacker, Yossi Benayoun, Andre Santos and Park Chu-young are available.
"I think Aaron Ramsey has been very influential in our team since the start of the season, but it is a good opportunity that we now have a big squad and that we can cope with it," Wenger told Sky Sports News.
"We have of course three midfielders out - Diaby, Wilshere and Ramsey - and it's many but we still hopefully have a strong midfield tomorrow [Tuesday]."
Arsenal (from): Szczesny, Fabianski, Sagna, Koscielny, Mertesacker, Djourou, Gibbs, Santos, Song, Frimpong, Arshavin, Walcott, Arteta, Benayoun, Gervinho, Park, Chamakh, Van Persie