Andre Villas-Boas must decide whether to recall Frank Lampard.
Lampard has started the last two matches on the bench and it seems unthinkable he will not be in the XI at the Mestalla.
Daniel Sturridge is expected to be fit after a knee injury, Ramires is available after missing the Blues' Group E opener against Bayer Leverkusen through suspension, but Romelu Lukaku is ineligible and Alex, Paulo Ferreira and Josh McEachran did not travel to Spain.
Chelsea (from): Cech, Ivanovic, Bosingwa, Terry, Luiz, Cole, Bertrand, Mikel, Romeu, Ramires, Lampard, Meireles, Mata, Malouda, Torres, Drogba, Anelka, Sturridge, Kalou, Turnbull.
