Michel Salgado will miss the game after a recurrence of a hamstring injury.
The Spaniard aggravated the problem in last weekend's 1-1 draw at QPR and his absence means Jason Lowe is expected to fill in at right-back.
Midfielders David Dunn (calf), Vince Grella (hip) and Ryan Nelsen (knee) are all still out.
Tottenham will recall the likes of Scott Parker, Gareth Bale and Rafael van der Vaart for the trip after resting them for Thursday night's Europa League win over Rubin Kazan.
Harry Redknapp has major problems in defence, however, with William Gallas (calf), Michael Dawson (Achilles), Ledley King (groin) and Vedran Corluka (foot) all unavailable.
Aaron Lennon (groin) and Sandro (calf) will be given fitness tests but should be fine to play after they both came through 70 minutes of Thursday's 1-0 win, but Tom Huddlestone remains sidelined with a long-term ankle injury.
Blackburn (from): Robinson, Lowe, Samba, Givet, Dann, Olsson, Givet, Petrovic, Nzonzi, Hoilett, Roberts, Bunn, Hanley, Formica, Vukcevic, Rochina, Yakubu, Goodwillie.
Tottenham (from): Gomes, Friedel, Cudicini, Bale, Kaboul, Bassong, Walker, Assou-Ekotto, Rose, Parker, Modric, Livermore, Townsend, Carroll, Lennon, Falque, Sandro, Pienaar, Pavlyuchenko, Defoe, Dos Santos, Adebayor, Van der Vaart.