Mauricio Taricco is set to play for Brighton.
The 38-year-old former Tottenham defender, now Albion's assistant manager, is poised to start at left-back as Marcos Painter is suspended.
Painter was sent off for two yellow cards during Saturday's defeat at Leicester and serves a one-match ban.
Boss Gus Poyet could add Will Hoskins and Vicente to his squad.
Striker Hoskins has finally recovered from the hip injury which has sidelined him since the opening day of the season and former Spain midfielder Vicente has been building up his fitness after joining as a free agent last month.
Poyet must also decide whether to risk young defender Lewis Dunk, who is one booking away from a ban.
Liverpool captain Steven Gerrard is set to end a six-month spell on the sidelines after groin surgery.
New signing Sebastian Coates is likely to be given a full debut in central defence while Craig Bellamy could get his first start since returning to the club last month.
Midfielder Charlie Adam and defender Martin Skrtel serve one-match bans after red cards against Tottenham at the weekend.
Liverpool (from): Reina, Flanagan, Carragher, Coates, Robinson, Spearing, Lucas, Kuyt, Rodriguez, Bellamy, Carroll, Doni, Kelly, Enrique, Wilson, Gerrard, Shelvey, Downing, Henderson, Suarez.
