Everton boss David Moyes has no fresh injury concerns ahead of the game.
Phil Neville could be set to return to the team having been an unused substitute for the last two games.
Apostolos Vellios and Royston Drenthe may be in contention for their first starts after both came off the bench to score in the 3-1 Premier League win over Wigan on Saturday.
It remains uncertain whether or not Louis Saha - who has been working his way back to match fitness - might feature following the French striker's decision to vent his frustration via Twitter at being left out of the squad for the Latics fixture.
West Brom striker Shane Long is doubtful after suffering a bout of flu.
Defender Gabriel Tamas will serve the second game of a three-match suspension.
Baggies head coach Roy Hodgson made 11 changes for the previous round at Bournemouth and is again expected to rotate his squad, although not to the same extent. The likes of Simon Cox, Marc-Antoine Fortune, Billy Jones, Gareth McAuley and Marton Fulop will come into contention for starts.
Everton (from): Howard, Heitinga, Hibbert, Neville, Distin, Jagielka, Baines, Barkley, Fellaini, Osman, Rodwell, Drenthe, Cahill, Stracqualursi, Mucha, Baxter, Bilyaletdinov, Vellios, Gueye, Saha, Coleman.
West Brom (from): Foster, Fulop, Reid, Dawson, Olsson, Shorey, Morrison, Scharner, Mulumbu, Thomas, Long, Odemwingie, Dorrans, Brunt, Cox, Fortune, Jones, McAuley, Mattock, Reyes, Hurst.