Charlton boss Chris Powell is set to tinker with his starting line-up.
The Addicks manager has named an unchanged starting XI for the previous six games, so is likely to give some of his fringe players an opportunity to impress against the Bees.
Powell has hinted that Yann Kermorgant will probably get a chance to impress him, after the striker came off the substitutes' bench to score in the last two games.
Goalkeeper Ben Hamer enjoyed four loan spells with Brentford, so will be hoping to retain his place against his former club.
Powell told the club's official website: "There's a rule about playing a certain amount of players. I'm going to have to assess them and see what XI I can put out."
Meanwhile Brentford boss Uwe Rosler will be looking for a reaction from his side when they make the short trip to Charlton.
The Bees were beaten 4-0 by Huddersfield in their last match but Rosler can recall former Addicks man Miguel Llera to bolster his defence. The Spaniard, who left The Valley in the summer, missed the Terriers loss through suspension.
The match could provide the perfect opportunity for winger Sam Saunders, who has been sidelined with a knee injury, to get some much-needed minutes under his belt.
Rosler saw his side muster just one shot on target against Huddersfield, so striker Mike Grella could be called up to replace either David Clarkson and Clayton Donaldson in attack.
However, the Griffin Park outfit remain without the services of winger Kirk Hudson (hip) and defenders Shaleum Logan (ankle) and Leon Legge (hamstring).