Aldershot go into their blockbuster showdown with giants United injury-free and in high spirits.
Dean Holdsworth's experimental line-up at Dagenham put paid to a run of four straight defeats in League Two, resulting in a dramatic 5-2 victory.
Striker Adam Smith made his full debut since joining on loan from Mansfield and is likely to continue against the Red Devils after setting up Jermaine McGlashan for his first goal of a brace against the Daggers.
The EBB Stadium is expected to be close to its full capacity of 7,100 as Shots fans flock to see Sir Alex Ferguson's Premier League champions, fresh from a shock 6-1 defeat at the hands of fierce rivals Manchester City.
Michael Rankine and Danny Hylton scored the goals that saw off the threat of Rochdale in the third round, and the latter will be looking to register his 11th goal in all competitions.
Ferguson is set to make a host of changes to his United side.
Nemanja Vidic, who sat out Sunday's game following his sending-off in the Champions League win over Otelul Galati, is among those who could come back into the team, along with Michael Owen and Dimitar Berbatov.
Jonny Evans is suspended after his red card in the City game.
Man United (from): De Gea, Lindegaard, Amos, Smalling, Ferdinand, Vidic, Evra, Fabio, Jones, Park, Carrick, Fletcher, Valencia, Nani, Anderson, Young, Owen, Berbatov, Macheda, Diouf, Hernandez, Rooney, Welbeck, Pogba, W Keane, Brown, M Keane, Thorpe, Fryers, Cole.