Thomas Vermaelen could make his comeback from a two-month Achilles injury layoff.
With one eye on Saturday's derby at Chelsea, manager Arsene Wenger is likely to rest the likes of Laurent Koscielny, Per Mertesacker and Robin van Persie, and give starts to the fringe players like Alex Oxlade-Chamberlain, Francis Coquelin, Park Chu-Young and Emmanuel Frimpong.
Carl Jenkinson (knee), Abou Diaby (ankle), Kieran Gibbs (stomach), Bacary Sagna (leg) and Jack Wilshere (ankle) are unavailable.
Bolton boss Owen Coyle will ring the changes.
The likes of Adam Bogdan, Zat Knight, Gretar Steinsson, Fabrice Muamba, Mark Davies, Ricardo Gardner, Gael Kakuta, Ivan Klasnic and Tuncay Sanli are set to come into the team, while youngster Joe Riley will feature in the squad.
On-loan defender Dedryck Boyata, who came off with an ankle problem in Saturday's 2-0 Barclays Premier League defeat to Sunderland, is ineligible for this game but Coyle hopes the Belgian will be available for the trip to Swansea at the weekend.
Arsenal (from): Fabianski, Szczesny, Mannone, Martinez, Mertesacker, Koscielny, Miquel, Vermaelen, Song, Frimpong, Ramsey, Coquelin, Miyaichi, Ozyakup, Aneke, Watt, Arteta, Gervinho, Van Persie, Walcott, Park, A Santos, Benayoun, Oxlade-Chamberlain, Djourou, Rosicky, Arshavin, Chamakh, Squillaci.
Bolton (from): Jaaskelainen, Wheater, Steinsson, Cahill, Knight, Eagles, Robinson, Muamba, Reo-Coker, Petrov, K Davies, Klasnic, Tuncay, Bogdan, Gardner, M Davies, Pratley, Ngog, Blake, Kakuta, Riley.