Tim Cahill and Louis Saha could return to the Everton starting line-up with boss David Moyes set to make changes to his side.
Cahill and Saha could be recalled having both come off the bench - with the latter scoring - in the 3-1 Premier League victory over Fulham on Sunday.
Moyes says he has "a few knocks" in the squad to assess, while James McFadden, who rejoined the Toffees last week, is still working his way back to full fitness after the serious knee injury he suffered last season.
Victor Anichebe remains sidelined with a groin problem.
Chelsea look set to turn to their youngsters and fringe players once again.
The likes of Romelu Lukaku, Josh McEachran, Oriol Romeu, Ryan Bertrand, Salomon Kalou, Florent Malouda, Alex and Paulo Ferreira will all be expecting to feature after starting in the previous round against Fulham.
Didier Drogba, Ashley Cole and Jose Bosingwa are all suspended and Raul Meireles is cup-tied, while everyone else who started Sunday's controversial Premier League defeat at QPR could be rested completely or on the bench.
Everton (from): Howard, Heitinga, Hibbert, Neville, Distin, Jagielka, Baines, Barkley, Fellaini, Osman, Rodwell, Drenthe, Cahill, Stracqualursi, Mucha, Bilyaletdinov, Vellios, Gueye, Saha, Coleman, Hahnemann.
Chelsea (from): Cech, Ivanovic, Alex, Ferreira, Terry, Luiz, McEachran, Mikel, Romeu, Lampard, Mata, Malouda, Torres, Anelka, Sturridge, Lukaku, Kalou, Turnbull.