Defender Jonathan Woodgate could return for the game after three games out with a calf injury.
Winger Jermaine Pennant will be assessed ahead of the Britannia Stadium clash with his former club after missing the last two matches with a hamstring problem.
Danny Higginbotham, out since April with a knee injury, could be involved as he looks to step up his comeback after playing for the reserves.
Liverpool have Lucas Leiva available again for the clash with Stoke after the midfielder completed his one-match suspension.
Reds boss Kenny Dalglish is expected to make a number of changes for the tie, although Craig Bellamy will be hoping to keep his place having scored in Saturday's 1-1 Premier League draw with Norwich.
Daniel Agger made his return from injury as a substitute in that game and could be among those coming into the team.
Stoke (from): Begovic, Sorensen, Nash, Wilson, Huth, Shawcross, Upson, Woodgate, Higginbotham, Wilkinson, Shotton, Whelan, Delap, Palacios, Whitehead, Arismendi, Diao, Etherington, Walters, Pennant, Crouch, Jerome, Jones.
Liverpool (from): Reina, Kelly, Carragher, Skrtel, Agger, Enrique, Henderson, Gerrard, Adam, Downing, Lucas, Kuyt, Suarez, Doni, Johnson, Coates, Aurelio, Flanagan, Spearing, Rodriguez, Bellamy, Carroll, Robinson, Wilson.