Wolves boss Mick McCarthy confirmed that he will make changes to his side.
Adlene Guedioura, Nenad Milijas, Sam Vokes, Dorus De Vries, Jody Craddock, Stephen Hunt, Matt Doherty, David Edwards and George Elokobi will come into contention to start.
But defender Ronald Zubar's hopes of a comeback have been dashed after he suffered a groin injury during training.
Owen Hargreaves has been ruled out of City's plans.
Hargreaves, who made a goalscoring debut for City in the last round, would have been in line to play as manager Roberto Mancini considers a number of changes from the winning derby line-up, but has a slight calf niggle.
Mancini otherwise has a fully-fit squad to choose from.
Wolves (from): Hennessey, De Vries, Stearman, Johnson, Berra, Ward, Craddock, Doherty, Elokobi, Hammill, Henry, O'Hara, Jarvis, Guedioura, Milijas, Hunt, Edwards, Ebanks-Blake, Doyle, Vokes.
Manchester City (from): Hart, Pantilimon, Taylor, Richards, Zabaleta, Lescott, K Toure, Kompany, Savic, Clichy, Kolarov, De Jong, Milner, Barry, Y Toure, Johnson, Nasri, Silva, Dzeko, Balotelli, Aguero, Razak, Suarez, Bridge, Rekik, Scapuzzi, Onuoha.