Charlton will be without skipper Johnnie Jackson.
Jackson suffered a hamstring injury towards the end of the 1-0 win at Brentford last weekend and could be out until the new year.
QPR loanee Hogan Ephraim looks set to make his full debut on the left of midfield in Jackson's place while defender Matt Taylor takes the captain's armband.
Boss Chris Powell is otherwise expected to name an unchanged line-up, although Darel Russell could be added to the bench after completing a loan move from Preston on Thursday.
Fellow midfielder Dale Stephens is the only other injury absentee for the leaders as he continues his recovery from an ankle operation.
Huddersfield's new loan signing Jon Parkin could go straight into the starting line-up.
Cardiff striker Parkin has joined until mid-January and could be a straight swap for Alan Lee, who sits out the first game of a three-match ban, alongside leading goalscorer Jordan Rhodes.
But manager Lee Clark also has the option of recalling Lee Novak to the starting line-up, in which case Parkin will start on the substitutes' bench.
Another loan deadline day capture, defender Alex Bruce, could also feature after joining from Leeds.
Clark has no other new injury or suspension worries and is not expected to make any further changes as his side look to extend their record-breaking 43-game unbeaten Football League run.
Midfielder Oscar Gobern is pushing for a recall to the matchday squad following an ankle injury and goalkeeper Alex Smithies remains the only long-term absentee after knee surgery.