Swindon have only a handful of strikers to choose from.
Manager Paolo Di Canio is down to just two first-team forwards after Lukas Magera picked up a hamstring injury in the midweek Johnstone's Paint Trophy victory over AFC Wimbledon. Cristiano Montano has returned to West Ham at the culmination of his loan spell and on-loan Jake Jervis was blocked from playing by parent club Birmingham.
To make matters worse for the Robins, Algerian front man Mehdi Kerrouche is rated 50-50 by Di Canio to make the tie after suffering a knock against the Dons.
Should Kerrouche not make the starting line-up, Di Canio will use Raffaele De Vita - who has been operating wide on the left for most of the season - alongside Alan Connell up top.
Midfielder Ahmed Abdulla has been ruled out for a fortnight with a leg problem, while full-back Liam Ridehalgh is on loan from Huddersfield and has not been given permission to play by the Terriers.
Wes Foderingham, who is one clean sheet away from equalling the record number of successive shut-outs by a Swindon stopper, may come back into the side in place of Phil Smith despite Smith saving three penalties in the shoot-out win on Tuesday.
Huddersfield will be without leading goalscorer Jordan Rhodes.
Rhodes, who has scored 13 goals in 15 appearances for The Terriers this season, has been called into the full Scotland squad for Friday night's friendly with Cyprus.
But fellow striker Alan Lee is available again following suspension and could go straight back into the starting line-up alongside Lee Novak.
Manager Lee Clark will be forced into a reshuffle at the back because right-back Jack Hunt sits out a one-game ban after reaching five yellow cards for the season and another defender, Liam Cooper, does not have permission to play in the competition from parent club Hull.
Midfielder Oscar Gobern is still struggling with an ankle injury that has kept him out in recent weeks, but winger Danny Ward (shin) is fit again and hoping to play against Swindon, where he spent half a season on loan in 2009/10.
Goalkeeper Alex Smithies (knee) remains Huddersfield's only long-term absentee.