Arsenal defenders Laurent Koscielny (knee) and Kieran Gibbs (groin) face fitness tests ahead of the north London derby.
Midfielder Aaron Ramsey (ankle), defender Francis Coquelin (hamstring) and centre-half Sebastien Squillaci (groin) are all sidelined.
Defender Carl Jenkinson recovered from a back problem and played for the reserves in midweek, but centre-back Per Mertesacker (ankle) is a long-term absentee, along with full-back Andre Santos (ankle), midfielders Abou Diaby (hamstring) and Jack Wilshere (ankle).
Tottenham forwards Emmanuel Adebayor (knee) and Rafael van der Vaart (calf) have trained this week and are expected to be fit.
Benoit Assou-Ekotto (groin) and Luka Modric (illness) missed last week's FA Cup game but should also be available to play at the Emirates.
Ledley King (knee) faces a late fitness test, Sandro is a major doubt due to a calf injury, and William Gallas (calf) and Tom Huddlestone (ankle) are long-term absentees.
Arsenal (from): Szczesny, Gibbs, Vermaelen, Koscielny, Sagna, Song, Arteta, Gervinho, Oxlade-Chamberlain, Walcott, Van Persie, Fabianski, Benayoun, Arshavin, Chamakh, Park, Rosicky, Miquel.
Tottenham (from): Friedel, Gomes, Cudicini, Assou-Ekotto, Rose, Kaboul, Khumalo, Walker, King, Dawson, Nelsen, Livermore, Sandro, Parker, Bale, Kranjcar, Lennon, Dos Santos, Modric, Defoe, Adebayor, Van der Vaart, Saha, Lancaster, Luongo.