Wednesday boss Gary Megson could be without captain Rob Jones.
The 32-year-old has missed the Owls' last two matches after suffering a back injury in the Boxing Day defeat at Walsall.
Spanish defender Miguel Llera has been deputising for Jones but has returned to Blackpool following the end of his loan, so Mark Beevers could start if Jones is not fit, after returning from a loan at MK Dons.
On-loan winger Ben Marshall has been barred from playing in the FA Cup by his parent club Stoke so David Prutton or Jermaine Johnson are in line to replace him on the left.
Striker Gary Madine remains sidelined with a broken toe and defender Lewis Buxton (hamstring) is another long-term absentee.
West Ham boss Sam Allardyce is expected to make changes.
Promotion back to the Premier League remains Allardyce's priority, although he will not want a repeat of this season's Carling Cup when a much-changed side were dumped out at home to Aldershot.
Youngsters such as Frank Nouble, Robbie Hall and Dan Potts could feature alongside more experienced names like Freddie Piquionne and Gary O'Neil, who is building up his match fitness after a long-term ankle injury.
Defenders Herita Ilunga and Callum McNaughton could also come into consideration after returning from loan spells.
Abdoulaye Faye (thigh) is close to returning but may not be risked while Matt Taylor (calf) and Guy Demel (thigh) are still missing.