City welcome back midfielder Yaya Toure and defender Kolo Toure for the round-of-32 first-leg tie.
The brothers, who have been playing in the African Nations Cup, are due to link up with the City squad in Portugal on Thursday night.
Striker Mario Balotelli is also in contention after serving a domestic suspension but fellow forward Carlos Tevez, back from his self-imposed exile in Argentina, is not registered to play.
Man City (from): Hart, Pantilimon, Richards, Zabaleta, Kompany, Lescott, Savic, K Toure, Clichy, Kolarov, Nasri, Milner, Johnson, Y Toure, Barry, De Jong, Pizarro, Silva, Aguero, Balotelli, Dzeko.
