Rio Ferdinand will skipper United against the Dutch giants.
Ferdinand takes over the captain's armband as Patrice Evra is rested.
Ryan Giggs (ankle) also misses out, as does Dimitar Berbatov, who was injured in training on Tuesday. Nani (foot) and Phil Jones (ankle) return after missing the last four matches.
Man United (from): De Gea, Amos, Fryers, Rafael, Fabio, Jones, Evans, Ferdinand, Smalling, Young, Pogba, Cleverley, Scholes, Park, Valencia, Nani, Carrick, Rooney, Welbeck, Hernandez.